Numpad is an option, but you lose the wireless
Yes you can have a numpad, but you lose the wireless. Rather spoils the look, I think.
The Fn and Control keys are only on the left side. So a simple "Del" operation requires two hands rather than one. Other operations require three keys instead of two. It's needless productivity-bashing.
Typical example: if you're bouncing around an Excel sheet, Ctrl-End takes you to the bottom-right corner, Alt-PgDn moves one page to the right, Ctrl-PgDn moves to the next tab. On a standard PC keyboard - even on most laptop keyboards - you can do all those with just your right hand. The same operation on the Mac wireless keyboard needs two hands.
If you're a leftie, that means taking your left hand off the mouse, pressing the Fn key, then trying to remember which combo means PgUp and which combo means Home, then putting your left hand back on the mouse.
I have both an iMac and a PC, and I consistently find that I'm more productive on the PC. The Mac is fine for surfing the internet and for media consumption, but little annoyances like the keyboard and the over-sensitive mouse are too tedious for getting work done. (And don't get me started on the glare from those glossy screens!)