I use most of them...
Edge works better with one cloud platform.
Chrome, well SRWare Iron to be precise for some things.
Firefox for the platform I look after
IE for our intranet.
Not a single one work wells with everything.
Edge can screw up with some buttons and input fields
Chrome, decides not connect to legacy kit due to old encryption protocols...after all plain text is better than out of date protocols.
Firefox, is now stuck on a old version because they decide to no longer support Java, but the other browsers don't work correctly.
IE because the intranet fails to render properly.
So basically every single one has issue