The next giant leap
We already know how to improve the performance of computers by several hundred percent - possibly by some orders of magnitude. It doesn't involve any technologies we don't already have. Nor does it require any major changes so far as the users are concerned. Indeed, for them, the improvements will be pretty transparent - expect for the screamingly fast performance they will see.
What is this change? Not new hardware, just properly designed and written software.
It's time to toss the bloated, inefficient existing software - with it's mess of interdependencies, incompatibilities and patched patches and start teaching people to write clean code with low overheads and that does no more than is required of it. At present the world of software development works on the same basis that NASA used for its moonshots: waste anything but time. In this case, time to market.
So we have software tools that put programmer productivity before runtime performance, resource requirements and size - on the basis that technology will provide whatever is necessary to run this stuff. That's fine while the curve is still on its upward climb and hardware is getting cheaper all the time. But all "S" curves reach their limits, eventually. Sooner or later the hardware won't be getting faster every year and then we'll start to see push-back from users who won't accept the Minimum Hardware requirements and will look for software that runs on their existing systems.
We already get this on smartphones and tablets, where a typical Android app weighs in at a few megabytes, compared with the hundreds of MB needed for a PC (or Linux) based package.
You never know: the root-and-branch reworking needed to remove all the cruft that existing software has accumulated over the decades might even give rise to more secure designs and possibly even less buggy code (and will definitely obviate all the workarounds built in for backwards compatibility). It's unlikely that the corporate behemoths will want to play, since this attacks their fundamental existence. But that might just be another advantage.