The more things change, the more they stay the same.
Yes, those who have the "extra X chromosome" have problems in LOTS of places. I take the example of my mom. In her youth, she went to a VERY prestigious business school in a place that was to become Silicon Valley. This was before WW2, and females were very odd in this line of classes/work. She told me that there were only 4 females in the class (over 100), and at times they went of field trips. Of course she "dressed the part" and was considered "one of the guys". One particular field trip she went on she noted that a machine had broken down, and was in need of repair "right now". At that point she increased her vocabulary of words quite a bit as she heard lots of $%^&#@ words.
Yes, things have improved since then, but in lots of places some people (there are lots) are considered "second class" due to a physical characteristic (take your pick). It is unfortunate, but it happens. The good thing is that these incidents are decreasing with time. We can only hope that things will improve.
Yes, mom is still with us, and will be 95 next month.