Re: Going while the going's good
"sheer payload to LEO in a single shot"
A mere stepping stone to a lunar cargo "space truck" hauling whatever we want [people, stuff, etc.] to and from the moon on a regular schedule. Personally, I think this is the best model to use.
It's that first part of the journey that's the most expensive, getting to LEO. Example, Apollo missions, where the 1st 2 stages lift the 3rd stage and LEM + Command Module into LEO, then 3rd stage pushes the LEM and Command Module into a Lunar trajectory, The vast majority of fuel [and rocket] was spent just getting to LEO.
So it's "UNIX Principle" applied to rocketry: "do one thing, well" - use the LEO tool to get the "space truck" and its fuel+cargo into LEO, then re-use the truck a bunch of times hauling the cargo+people.