A couple months ago on my home computer (which has several Linux distros installed and which all share a common /home because I apparently like to make life difficult for myself - and yes, that's as close to a logical reason I have for having multiple distros installed on one machine) I was going to get rid of one of the extraneous Linux installs and use the space to expand the root partition for one of the other distros. I realized I'd typed /dev/sdc2 instead of /dev/sdc3 at the same time that I verified that, yes, I wanted to delete the partition. And sdc2 is where the above mentioned shared /home lives. Doh.
Fortunately I have a good file server and a cron job running rsync every night, so I didn't actually lose any data, but I think my heart stopped for a few seconds before I realized that.