Reply to post: Re: I am wary of this development

Now boffins are teaching AI to dial up chemo doses for brain cancer

Bilious

Re: I am wary of this development

Response to the drugs in question may be influenced by lots (really) of genetic and nongenetic variables in both the host and the tumour. One part is pharmacokinetics in the host - the overall fate of the drug substance after administration. Another is pharmacokinetics in the tumour - diffusion into areas and cells and organelles where the action takes place. A third is mapping of the pharmacodynamic susceptibility of each malignant clone in the tumour, and the variation of activity-related susceptibility in each cell. And how successful was the surgery?

Details about the behaviour of old anticancer drugs will have to be mainly guesswork with very poor predictive value for an individual patient. Most of the microdetails needed are unavailable to the doctor ahd his/her computer program. And who knows what is relevant, and the weight of each variable?

I would not invest in this project or the people behind it.

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