I actually install the *game binaries* in /opt/windows/Games and add this as a drive in winecfg. Cleaned out prefixes can sometimes need reruns at registry setup, but in general (WOW, Wolfensteins, SimCity and a few others) it's not been an issue for me. It also allows multiple users on the box to access the games (group account), although updates to WOW and Sims3 will choke on ownership on occasion, it takes only a moment to resolve.
Biting the hand that feeds IT
