Small problem: world faces big shortages of air freight capacity
The solution to this is to increase the number of dedicated air freight aircraft. There's a use for old A380s if operators want to upgrade to the A380neo.
Most freight aircraft are converted ex-passenger planes. If the challenge is to keep them flying longer (beyond their normal airworthy lifespan) without endangering lives, why not remove the pilots and have them operate as freighter drones? To reduce the risk to people on the ground, re-route the flightpaths / choose runways to avoid populated areas.They say planes practically fly themselves, so why not let them?