I have all the versions to date, and enjoy them all, different views of the same movie and I read the book before I saw the premier of the original in London years ago. To a degree Blade Runner is only understandable if you have read Do Androids Dream... but the real magic of the movie is that it invites the viewer to discover the question after the end of the movie ... that's real movie making.
I just hope that the sequel preserves the ambiguity, because to reveal an "answer" would destroy the movie. PK Dick's work is all about questions, not answers.