Re: limited availability on Linux/OSX
Bioinformatics is like that also. A lot of our older instrumentation is Windows-only and under support contracts that probably would not be concordant with VM's, and many third-party licensed applications are Windows exclusive.
That said all the open source stuff that we also depend on is heavily oriented toward Linux/POSIX. This actually causes problems with training since working here is often the first time that some of the younger generation has ever used a non-Windows PC.
Companies providing modern next-generation sequencing equipment and the computers to run it have also taken a giant step away from Windows dependency and I can say professionally that this is a great benefit towards support, reliability, and development.