Creationists don't tend to worry about science much, so they might ignore that, but I think I've hit on a compelling argument for anyone coming from an Abrahamic perspective.
The problem is the foreskin. Why would a designer deity add something to the male body and then the moment they get in touch with their creation immediately demand that it should be cut off? Surely either the designer would be imperfect or the insistence on removing it would be an insult to the creator. Either way the core tenet of a perfect creator is undermined.
If foreskins don't make sense you must acquit my client!