My data point
Phenom 2 quad core running on Toshiba C650D
Did over-install on fresh 7 Home Premium x64 with a single update.
Seemed to work, found most of the drivers but since the Anniversary Update I've had two (!) random restarts with no apparent cause.
CPU temperature at the time was well within AMD's spec and this has the latest BIOS and chipset/fan/hotkey drivers but was reporting before the update an athbtx related problem on each boot or recovery from sleep/standby.