Re: People who use adblockers...
The advertising is not just wasted, it's worse than that.
People who don't want to see ads yet have to tolerate ads being forced on them will get annoyed. If it is your ad that has annoyed them, then you will lose goodwill with that person and probably a potential customer too, because your company / product is associated with irritation and annoyance.
If your ad runs scripts that cause my web page to freeze, jump about while images load, or places a big panel over the top of what I want to look at with a difficult to find X to close it, then you can fuck right off and die and take your products/services with you because I will never want any business with you.