check-out?
I've struggled with the flakiness of OneDrive for business and its predecessors for several years. The most recent problem is that it now doesn't work against document libraries which require check-out/check-in (this is by design with the latest update).
Now it becomes apparent that this change was probably the first step along the way to getting rid of ODFB altogether and replacing it with the consumer OneDrive. Assuming that the new unified OneDrive doesn't support check-out/check-in either, that will be another big nail in the coffin of anyone who wants to use SharePoint or office 365 as a document management system.