When you can't hold it in your hand, or worse you have to right click on it
Time and time again I work with skilled engineers who can (and do) rebuild jet engines, steam engines etc. they are by far the most frustrated by computer work. My conclusion is that they cannot get their hands dirty in order to fix the problem. Likewise, people cannot pick up, hold and test out computer tools. It all has to be done in the mind, and in my experience most people cannot get their head around this lack of touch / needing to visualise the problem, layer by layer.
For the record, my 84 year old mother is very good with her PC and email (especially once I got her off Outlook Express) but every time there has been a right click on the mouse, the question comes back 'left click now dear?' - I have replied with all the polite versions of 'it's left click unless I say right click' for 12 years now without effect.