Long haul
Living on the other side of the world from the rest of my family I have flown a fair bit in the last few years. Key points are:
1) bring noise cancelling headphones
2) minimise any connections, but make sure you have a couple of hours transit time (it's terrible to be 30 mins late and then wait 8 hours for the next connection).
3) avoid Heathrow and the US. Fly into CDG or Schipol then to UK regional airport. Or via Dubai and Glasgow/Newcastle/Manchester/wherever else they land. Friendly customs and immigration, no ridiculous queues; minimal security theatre just appropriate security.
For short haul, I can only suggest this is best doing aeromedical retrievals - get ambulance to airport, walk through building onto apron, climb steps, pilot asks if it's ok to go now, you say yes. Reverse on landing; ambulance to taxi you to the hospital. Stroll in wearing flight suit; get treated like a god; provide reassurance then reverse back to original hospital. (NB: there is a higher-than-usual chance of needing to provide in-flight medical assistance, and there's no booze.) Additional upsides are flying on non-standard routes at much lower levels (nice countryside), getting to sit in the cockpit when there's not a patient, and having a headset to chat to everyone else. Oh, and you get paid to do this. Awesome.
(the only thing better is going in the helicopter)