So, what overflows?
The usual reason for this is a 32 bit counter of milliseconds overflowing, but that happens after 49 days and 17 hours, approximately.
I still remember when someone managed to run Windows for 50 days without a reboot for the first time...
Now, it would seem to me that Cisco have learnt that lesson and use a 64 bit counter. Unfortunately, they also decided to count picoseconds...
$ echo '2^64/18446400/10^12' | bc -l
1.00001865262108333420