El reg needs to read the article...
Did anyone ACTUALLY read this article?
The compound they used is ellagic acid which has naff all chance of passing through the gut with out being munched on by bacteria ( the clue is it is too big to diffuse so it must be broken down).
You can put any number of things on a bunch of cells and I'm sure they'll dance. That doesn't mean they aren't responding in vivo, it is just unlikely the gut will present as much material. To their credit the authors point out the mouse gut is not a good model for humans.
I would be more persuaded if they had put the mice on treadmills and forced them to do exercise as well. Note, they did measure oxygen uptake on some human cells, but to be a really effect test varying the metabolism would be better in vivo so we know it is "normal". Inbred lab mice in sedentary conditions might be a good model for the worst of humanity, but it is a very weak association otherwise, because the assumption is the liver is working properly.
Finally, I noticed they cite themselves and the previous study where the experiments were done and this data is not available to me, how about El Reg? I'd be interested in seeing the mouse samples.
El Reg D- , please see me after class.