Use the proper ammo...
and even the .380 becomes a viable defense option - for those of us who choose to accept the responsibility; and are still allowed to defend ourselves with a firearm.
https://www.youtube.com/watch?v=LczfeWK9lHw#t=17 Ammo Quest .380 ACP: Lehigh XP Xtreme Penetrator test in ballistic gel
https://www.youtube.com/watch?v=-PDQcE-1T40 Military Arms Channel Lehigh & Underwood .380 Xtreme Perpetrator
$1,350 is too rich for my blood, and IMHO one round is not enough! I'll keep my Smith & Wesson Bodyguard. ;<)
Given time, avoidance and 911(or equivalent) are still the best options. However, much of the time some means of defense is required to buy the time. All too often less than lethal options are insufficient. YMWV