Now we can have real fish fingers!
It’s a pretty safe presumption that hands evolved from fins, since fish evolved long before anything remotely resembling an opposable thumb. Now, a group of Spanish researchers has demonstrated a genetic expression that hints at how it happened. The group, led by Dr José Luis Gómez-Skarmeta of Spain’s CSIC-Universidad Pablo de …
Now we can have real fish fingers!
Not sure about experiments to create prawn balls though!
we should give dolphins hands
*clap* *clap* *clap*
Dolphins are not fish.
I don't think t_lark ever claimed they were.
Technically they already have them. The bones of a dolphin's flipper are equivalent to the bones of a human hand, they're just shaped slightly differently and wrapped in a big lump of flesh .
I don't think Pookietoo ever claimed t_lark claimed they were.
Oops, leaving myself wide open...
They've spent millions of years of evolution to get rid of hands and now you propose to force it back on them?
...and he said he was a fish. So that's settled.
they don't have hands - they have a structure that is the homologue to our hands - send me a dolphin's autograph if you disagree
Do you got a number for that chick in the photo? Thanks!
You must be very drunk indeed...
I'd give her a 3 though. But then, I'll take anything with hands...
She looks like a pokemon reject.
Handfish I choose you!
Not just hands but a nose, big mouth, two legs.........and a big belly. Must be a Greggs girl.
I think she's an "ex" of mine... hang on, I'll see if I can find her number in my phone...
So can we subtract this gene from humans to make mermaids?
Some think they exist anyway.
How exactly do you.... Y'know... With a mermaid?
Actually, on second thoughts, maybe I don't want to know.
Ah, but is it a top-half mermaid or a bottom-half mermaid?
I prefer barmaid.
Most of the barmaids around here look like dugongs anyway...
They need thumbs.
Ernest Hemingway's do...
There’s no hint that Dr Gómez-Skarmeta plans to try the same trick on sharks, thankfully.
Sharks are not fish. Fish have bones. Sharks have cartilage, rather than bones (although they do have boners).
Whether sharks have 5’Hodx, I have no idea.
Peter Benchley did this years ago... with Sharks!!
Sharks are cartilaginous fish. So... um... yes... sharks are definitely fish. As are skate, dogfish, rays, etc.
I would think so.
hox ("Homeobox") genes are basically developmental switches under which lives a cascade of other goodies.
They exist in fruit flies, so my guess is sharks have them.
Hox experiments are real Frankenstein affairs.
For example, it's possible to pursuade a fruit fly to grow a leg where it's antenna should be.
Any time you see developmental mutations, eg missing limbs, extra toes, etc: chances are you can point the finger at a Hox screwup.
Shark fins are much further away from tetrapod limbs than teleost (bony fish) fins. Fish fins are movable, they have discrete blocks of muscle and bones that are the precursors of humerus and femur. Shark fins have no cartilage equivalent and the muscles are segmental strips that just allow the shark to trim the fin. The main functional difference is that sharks can only swim with their tails whereas bony fish can hover, or even go backwards using their pectoral fins which are very mobile.
So doing this experiment in a cartilaginous fish would make no sense.
As for the research, I would need to see how the extra growth is generated before reaching a firm conclusion that these are 'autopods'. as claimed. But as a proof of principle it is intriguing.
Does that mean the first humans were Finnish?
/Taxi for one.
"All of the fish that took up the gene developed autopods rather than fins within a day. However, the genetic experiment was also fatal to the fish."
Sounds like an evolutionary dead end to me...
I was going to see about getting a couple of extra hands, until I read the bit about the procedure being 100% fatal. Back to funding cybernetic research.
Tag it a joke all you want, but obviously this alone is not how it happend. Until we can come up with something that allows the hoxd13 expression to be non-fatal, we can't be vary sure that's what happened at all. Maybe something else modified 5’Hodx transcription.
Interesting, and a couple of good lines of continued research, but it "hints" the same way as our knowledge of physics "hints" at the possibility of a Alcubierre drive. I still don't plan on launching next week!
Go on more research!
Some years ago some boffin, use the same trick by injecting some tooth gene into eggs.
The resulting chicks had teeth.
"chicks had teeth" sounds just like my missus ...
Or they might become filthy, antisocial, neckbearded basement-dwellers with a propensity for condescension and self-righteousness. Then you'd have a peer group!
I think it's fitting that it looks like the new life-form is saying "Howdy-ho!", it being Christmas-time and all.
although it was a foot, rather than a hand, but autopods can express as either, apparently.
Toward the end of Chapter 8, as I recall.
Perhaps because the original paper is behind a paywall, the stories describing it have wandered off the proper path into the quicksand.
The underlying question is, can we propose a plausible way (evolutionarily and genomically) to go from your extremities being fins to your extremities being rather more physically substantial (the stump-like "autopods"). This paper suggests that the answer is "yes."
The authors of the paper hypothesize that all you have to do is to crank up the amount of the product of the genes near the 5' end of the hoxd gene complex (a set of hoxd genes lined up in a row on the chromosomal DNA) and Bob's no longer a flounder, but rather your stumpy uncle. Essentially, hox genes are expressed at different levels in different regions of the developing embryo, and act as part of a code that directs each such region what type of structure to form. The authors think that boosting amounts of one of the 5'hoxd genes, hoxd13, throughout the developing extremity will make each subpart "think" it is closer to the fish's body, and to thus form a more robust structure than it would normally do. In particular, the cells in the very thin "finfold" region at the end of the fin instead will form a more thick and robust structure like that normally found further up the center of the fin. Thus, a fin becomes an "autopod" merely by boosting the level of a single gene product!
To test this, the authors try boosting hoxd13 levels by injecting a mouse version of the gene into the fish embryos; they see that those embryos with the gene do in fact form autopods instead of fins. (We assume that they did proper controls to show that hoxd13 levels increased compared to normal embryos, and that increased gene product levels caused the change, and not just the fact of using a mouse version of the gene rather than a zebrafish version) OK, so boosting a 5'hoxd gene DOES cause changes that look like extremities becoming autopods instead of fins.
Now, how might one boost 5'hoxd gene levels in a straightforward evolutionarily-plausible way (mouse-gene-injecting biologists having been rather thin on the ground hundreds of millions of years ago when autopods came into being)? The authors propose that genetic elements (DNA sequences) called "enhancers" might be the answer.
As their name suggests, enhancers boost the expression of nearby genes, and conveniently, tend to be much shorter than and much more robust to changes in their DNA sequence and location than are actual protein coding genes. Thus, it is plausible that a "new" enhancer might have been created by mutations near the 5' end of the ancestral tetrapod hoxd gene complex, or perhaps more likely, that a copy of an enhancer sequence from elsewhere in the genome (with some minor DNA changes to allow it to be controlled separately from its original) might have been spliced into the DNA 5' of the hoxd gene complex.
To test the plausibility of this enhancer hypothesis, it seems that the authors inserted an enhancer DNA sequence called "CsC", normally found 5' of the hoxd gene complex in tetrapods (but not fish), into zebrafish embryos. They found that it promotes nearby gene expression similarly in the zebrafish embryo fin regions and in its "normal" mouse limb environment.
Thus, the authors propose that fish fins evolved into stumpy autopods (later to become the slender limbs of fashion week runway models around the world) simply by the addition of novel enhancer DNA sequences in the region 5' of the Hoxd gene complex.
Paris, since her expression was certainly enhanced quite nicely.
Looks like a competent replacement for Joe Hart. Just a shame it's Spanish!
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