point to point for me
As someone who used to suffer more than a reasonable amount of time stuck in a sardine tube, one knee inserted up each nostril. I've got to say that I always looked to fly directly. If you couldn't get there directly from Heathrow then it counted as third world. Gatwick, perhaps at a push. To me it was the main reason to live in the SE.
Having to change planes is such a PITA.
The other advantage of smaller planes is that for busy routes you end up with more flights so can choose more convenient times to travel. Hopefully everyone is different and so what is most convenient for me, might not be for someone else.
In practice I think we'll end up with a mixture.