I will not say that it is all awful, but while I am relatively indifferent to much of the change some things are really annoying compared to the old version. This is before I checked different resolutions and stuff, or the mobile version (less important to me, but when I do use my phone I always use the normal websites, as some of the others here). I am using a big screen now.
1. I like having as much of useful stuff on the screen as I can. This means that I really do not like the new layout which either leaves too much whitespace or presents too little information, depending on zoom level/font size.
2. No need for oversized pictures, cute and funny as they might be - I'll appreciate the humour even if the illustrations are smaller. They are nice to have and they take a lot of space, making me scroll to the really useful content.
3. The categories menu - Data Centre, Software, Networks, etc. - pops a huge bar with pictures and headlines that covers half of my bloody screen when the mouse accidentally hovers over it - please get rid of this horrible "feature".
4. Search has become much more difficult to use - you need to hover over the magnifying glass symbol and only then the search bar pops out, to which you need to carefully navigate and keep the mouse cursor over it at all times. Very cumbersome. It was much easier in the old version.
5. The pages load weirdly - the main frame appears shifted to the right with a lot of whitespace on the left. Only when I scroll down to the point where a part of the heading [right now, "El Reg redesign - leave your comment here"] is no longer visible the main frame jumps to the left and the right frame (with Most Read, Spotlight, etc.) appears. If I scroll up to the heading the right frame disappears again. Happens for articles and comments alike. Very annoying. This seems like a bug and not a feature.
6. I liked the Most Commented feature. I find an unusually significant proportion of comments fairly intelligent, and knowing which topics generated most active reaction was useful, whether or not I eventually clicked on the articles.
[Firefox on Linux with AB+, if that matters. AB+ has the option of not keeping empty placeholders on the page enable - mentioning that in case it is relevant to the amount of whitespace I see.]