I bought a Crumpler half-photo about a dozen years ago when going on a long trip. I wanted something that could take a fair amount of gear, some knocking about and was waterproof. The only thing I could find was a Crumpler and I haven't regretted it.
They are expensive but do come with a 30yr guarantee. Mine has been sailing trips to Far East, on safari, a round-the-world and Cape-to-Cairo. I've carried laptops, cameras, phones, ext HDDs and accompanying paraphernalia without one item getting damaged or wet. Even when I'm drenched, the insides stay dry.
I cycled for years in London in all weathers and went over the handlebars a few times without any damage or damp.
I was leery of the price when I bought it, but now it seems a bargain, particularly as it's barely marked, has retained its structure and still gets the job done.
No, I don't work for them - it's just nice to get what you pay for and then some...