The biggest issue is always finding something else to do, instead of work.
Like reading 'the register'... ;) - the Internet is only your partial friend, it can also break your job completely.
I go for an hour's walk everyday, which has saved me from sciatica problems, and is great for blowing the stagnant feelings away, and it freshens my thinking, not to mention keeping me healthier than the beached slob-whale I could be.
As far as loneliness goes - man up you pussies!
Embrace the quiet. Or use the radio (SomaFM is good to work with)
And if you can't stand your own company then you need psychiatric help, ya looney. :D