This is the beginning...
This is from about 25 years ago, I didn't pursue it as a career, but since I worked in the offices organising the incoming and outgoing loads, this is the insight I received.
"Assuming it's a full load every time, that might work. A significant number of loads, eg beer to supermarkets, are not full loads."
Suppliers to the warehouse were mostly full loads. The warehouse staff would unload the delivery trailer whilst the driver had his "break", a legal requirement.
"Supermarkets tend to do their own deliveries to stores with all products on one truck and each truck doing multiple drops other than to the very largest superstores"
Each store received at least 2 deliveries per day; "chilled/frozen" and "ambient". If there were special offers or some sort of promotion there would be extra deliveries. I imagine the frequency of the deliveries increased at Christmas and other large festivals/holiday periods. Most of the trucks in the yard were 38 ton articulated vehicles (semis to our North American chums).
There were a fleet of smaller, "Less Than a Load", vehicles for hard to reach/smaller stores.
I see this as the beginning of a significant change in the trucking industry in less populated parts of the World. Possibly the largest expense of trucking is the driver. The driver needs compensation, needs a licence which must be maintained and they will probably cost more than the capital cost of the tractor/rig. With Otto doing most of the highway driving the driver will only be needed for the more awkward parts of the journey.
The reality is and has been demonstrated by this exercise, the technical part is relatively easy, the cultural and legal hurdles will be much more challenging, but I expect they will be overcome. At the moment Otto drives with a police escort, cars used to be escorted by a human with a flag.