I am now a chronic RSI sufferer
Rome: Total War was what tipped me over the edge. As a software engineer in the day and a gamer in the evening, I was fine until I wasn't. That is the problem, I cannot get rid of it now and can't use a mouse. Almost constant low pain which can make you feel sick. People do need to be warned about what they are storing up for their kids and make sure they don't use the computer too much. On the industry side, hopefully some of the great developments around alternative inputs and voice recognition will start to take hold in the next few years.