yes and no.
we can "see" a light/particle cone of ~13.7 billion lightyears. This is the "age" of the universe. This cone is all the material, from which there has been time since the inception of the universe, for light emitted from it to reach us.
We can reasonably assume that the universe is not cone shaped, and there is more universe then we can see, but due to the limit of the speed of light we can not "see" this material.
According to Relativity, as I understand, material that is outside of this light cone. (~13.7 billion year long cone which stretches from here -> Big Bang) can not affect us, nor can we affect it.
However... as a thought experiment(?)
We can imagine a particle Po (for Particle Outside) that is just outside of our light cone. There is material inside our light cone Pi (Particle Inside), where Po & Pi can interact.
Pi can/does interact with us as it is inside our light cone.
Po affects Pi.
Po affect us 'by proxy' through Pi.
I do not know how this is explained away, as I believe it is.