Re: "Nice one judge." That I am afraid is utter nonsense.
@AC 00:21
I'd be tempted to put more weight to your ability to quote wikipedia if I had any confidence you didn't just edit the article you're quoting. Even if [4] is true I don't see what relevant knowledge an editor of NEJM would have about the cost of doing something she doesn't do and is clearly a skeptic of anything she hasn't been indoctrinated into and had she been around would have banned Hippocrates himself of using tree bark tea for treating pain and fevers. Yes, her bio is on the in-tar-webs.
Also it would seem likely that a smaller company would incur higher costs initially in part because larger firms are likely to have certain capital equipment on hand that a smaller company would not invest in until it was needed such as a centrifuge or mass spectrometer. As an analog, a small manufacturer might only start with a single milling machine when they are developing a product but a larger company may have many mills, turning centers, injection molding machines, etc. waiting for work which would substantially lower the cost of doing an additional project.
"so it looks like in reality it can be anywhere from $55 million to a MAXIMUM possible of 2 billion."
I must admit I have no idea what to make of this. To say anything has "a MAXIMUM possible" can only stem from a naivete that is so grand and judgmental I can only ask; what do we mere mortals look like from so far upon high? LOL, "a MAXIMUM possible", you've never heard of government, have you little one.