Isn't this what happened on AF477?
Confused by conflicting information, the computer on the plane basically said "Fuc*k this for a game of soldiers, I'm outta here! Over to you blokes".
Problem was, the 'blokes' weren't sufficiently experienced to realise the severity problem, being reliant on the 'puuter to do the flying. The rest is history.
We're too bloody reliant on these systems, and not reliant on our own skills.
In the case of lessons learned from AF477 (and others) I think it should be mandatory for pilots to do something like 1/10 flights without autopilot, to re-learn how to fly a *real* plane, rather than a simulator.