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I have all three types of external drives attached to my computer so I just ran a brief test ... here's the result:

USB 2.0 Burst - 29 MB/sec ... Avg 29 MB/sec

FW Burst - 40 MB/sec ... Avg 40 MB/sec

eSATA Burst - 115MB/sec ... Avg 58 MB/sec (this is a SATA 1 drive)

eSATA is clearly superior in all respects.

One of the advantages of eSATA is that is is not seen as a removable device by NT based O/Ses and you can easily install your O/S on an eSATA drive.