It may just be...
...That in areas where our kind of life is impossible due to different chemistry, other kinds of complex chemical or energy systems might arise. One of the reason we are based on carbon instead of silicon, is that silicon bonds are of different strength. Perhaps in other places silicon is more suitable? Same goes for other elements.
The scary thing, however, is that a possibility of anisotropic (changing with location) constants opens up a possibility of anisochronic (changing with time) constants, in other words, that alpha might change in our region in the future, obliterating life as it does. We don't even know how large the change has to be to affect such a complex creature as ourselves. Not to mention the remote possibility of artificially changing said constants.
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