My email anti-spam system is still going strong after fifteen years. It's a variant of disposable addressing and grey listing. Every contact gets their own email address to use for me following a basic template. My mail server throws away any incoming mail that doesn't match the template. Everything else goes into my mailbox.
There's a small list of known offenders who also get blasted. Mostly small independent retailers. Which is why I rarely use those these days. The big boys seem better able to keep my data private.
Aside from making me immune to random spam it means I know who an email is supposed to have come from - I don't have to rely on the 'from:' field in the headers which is easily forged. I don't have to use any spam cleaning software and yet I almost never get any spam. If I do get some I can stop it dead by blacklisting the address without affecting anyone else and optional have a rant/quite word with the person who was assigned that address.
The latter doesn't always work though. The publishers of Avast claimed that the unique address I gave them must have been generated in a dictionary attack - despite the fact the server logs showed an otherwise normal day of a dozen random spam mails. I stopped using their product after that.