they should be rubbing it on athlete's feet!?

"If rapamycin - or drugs like rapamycin - works as envisioned, the potential reduction in overall health cost for the US and the world will be enormous."

Yeah, and the world population will expand massively too causing lots of other problems.... :-(

Kind of creepy that this magic anti-aging drug comes from an island with no indigenous animals left.

So you can live forever in a bubble.

Animals that only live a couple of years aren't fine tuned for longevity. They are tuned for reproduction, hiding, hunting, ability to eat rotten food, etc., but not longevity.

It is much easier to extend their life expectancy.

You can reduce the temperature of their living environment, or vastly restrict the calories in their diet, cut this or that out of their diet. There are many blind stabs in the dark that will extend their life spans.

It is not so easy with animals like humans that are already tuned for longevity.

mwuahahaha!

/me gets his dirty magnetized coat

The dodgy pharmaceutical spammers are really going to love this one.

First of all, when this comes along (If it does.) it's likely to be expensive. Which means it's likely to be used only in the wealthier countries. Which, coincidentally, already have shrinking birth rates, and would already have shrinking populations if it weren't for immigration from other countries with higher birth rates.

Secondly, all that aside, *I* personally would like to have another 20 or so good years, and I would like my friends and already existing family to have that, and I think that most people are likely to feel that way themselves. If that means that people are going to need to learn to live with having only one or two kids instead of three or four or more, I'm perfectly fine with that.

There have been a few posts above that run along the lines of "Anti-aging can't be good because it would lead to increases in population and greater demand on natural resources." or, following a more philosophical line of "Surely death is part of life and we must accept our fate" - the old Four Score and Ten line, as it were.

Now, whilst I don't wholly disagree with those sentiments (especially as regards over population), I'd like to take the opportunity to play devils advocate for a moment (I can almost never say that phrase without a recollecting Homer Simpsons Pinball machine. heh.)

* The ideal population for earth, according to NeoCon philosophy in the US is approximately 600k - Yes, six hundred thousand, less than 1% of current levels. This figure is the 'optimal level for resource sustainability' - well, we're already WAY outside of that!

* The largest populations occur in the least wealthy nations as a rule of thumb, so I doubt that they will benefit from the emergence of a (no doubt) very, very expensive designer drug in the west. We need only to look at how the various AIDS treatments have been handled to see the effect that such a drug would have on the 'emerging world'.

* It was only a century ago that the average life-expectancy of persons living in the western industrialised nations was around HALF of the current expectation, yet we don't complain that people are living too long by those standards. The idea that life is curtailed by some 'moral marker' in the form of 'an appropriate death following a suitable life' is purely a religious construct, and not a biological one. This increase in life-span is no less natural than the idea of a drug found in soil - we've brought it about through our science; understanding diet, surgery, and far less 'natural' drugs, as well as through social evolution. I don't hear anyone saying that these are bad things (well, maybe some religious fundamentalists, but they are barely worth listening to.)

* If resources were correctly managed, and not owned by vast multi-national corporations (who stockpile and waste on incredible scales) then the population of Earth could be easily sustained. It's not that there are insufficient resources, it's that the resources are owned by a tiny fraction of the global populace.

Overall, I think we should welcome anything that enchances the length and/or quality of life for all human-kind, but it should be a cautious welcome until we truly understand the ramifications of the technology in question.

And resource depletion is not a tightly coupled phenomenon.

Sometimes the commentors on this site need a good kick in the head, they remind me of rabid little Daily Mailers, oblivious to the wider world and their place in it.

Viewing the world through their monitor blinds them to the causes and processes occuring around them.

I blame the Medja ! Simple news for simple people has been their mantra for far too long, a rush to the lowest common denominator.

Another 20+ years of life.

Better stay working until I'm 80 then....

: (

"If rapamycin - or drugs like rapamycin - works as envisioned, the potential reduction in overall health cost for the US and the world will be enormous."

Not unless it causes an extension of healthy life followed by a rapid terminal decline.

If, as seems more likely, it slows down the ageing process, then it means that more people will develop one of the degenerative diseases of old age and then they'll stay alive with it for longer. So it will be robbing Peter to pay Paul -- making a short-term saving to health budgets but pushing a greater cost out a decade or two in time.

he always kisses the ground !!!!

Maybe, just maybe, suppressing the immune system is not such a brilliant idea, eh? I mean, it's not like we have a lot of antibiotics left to lean on in the fight against infections. I suspect this is a problem that will solve itself.

"...and I for one welcome our geriatric murine overlords...."

Rapamycin is used for transplants and, more recently cancer. It will thus be much more expensive than Viagra.

Regarding immune suppression, the idea of good drugs is to selectively block the immune system, rather than knock everything out. People with transplants survive fine, though they should take some care to check for infections and cancer.

However mTOR (look in Wikipedia) blockers are not really working via the classical immune systems. MTOR is a relatively recently recognized cellular mechanism which looks to be central, with any number of interesting effects. Wikipedia mentions losing weight, for instance.

Why did they decide to look at rats? I imagine the lifetime Tox. studies done by Wyeth must have already thrown up the property. Imaging explaining to your boss that the launch must be delayed for a year, because the rats aren't dieing properly.

Let's try a human trial on Bernie- then he could serve more of his 150 years sentence!

@Chris C:

But, what if there is an afterlife, and your god hates you?

The problems we have as humans don't care how old you get to be. If I may:

1. Population. Not everyone deserves offspring; pure and simple. You don't have to plonk out 12 kids anymore because 11 of them will die before the age of 10 - we are even able to keep deformed and crippled alive and suffering well into their their twenties and beyond. The idea that any one person's genetics are special enough *and that they are automatically passed on to all your offspring* is egotistical genetic avarice. Anyone attempting to "ensure" it happens (designer genetics, IVF, Catholics) are simply trying to have the bigger, badder, shinier SUV in their utereus. Err... carpark.

2. Resources. It does not matter whether a minority (person) or majority (corporation, gubmint, etc.) controls the resources of an area. If you give each individual all the resources they are apportioned or that they "need", the majority of them will squander the share they are given and kick and scream that someone else still has any when they come up short. That's the curse of "human nature"; we never have "enough". In order to live "sustainably", we have to bring everyone _down_ to a common standard of living, and all the death, disease, and pain that it brings. Oddly enough, Americans in 1700/1800's were more apt to do this as a whole society than any other; the mass migrations out of the comfortable cities into the wilderness and death of the Louisiana Purchase and the West. (http://faculty.wcas.northwestern.edu/~fe2r/papers/essay.pdf) There are others; don't get your panties in a bunch - just not as a percentage of population (without cause of volcanoe, glacier, war or other "natural" disaster). Try telling the newly middle-class in India or Russia that they have to go back to "sustainable" levels - no cars, no unlimitied electricity (if any at all), all the food you eat you have to grow/raise yourself. Not many volunteers, eh?.

3. Religion. Religion has nothing against longevity. Judism (and by extension, Christianity and Islam) have published how our ancestors lived for hundreds of years. If you are _really_ bored, try calculating out the ages of everyone in "Numbers" for yourself. There is nothing inherently "righteous", noble, or grand about living a short life or a long one; its always about what you do with your life. If you are a rat b@stard who lives 200 years or 12 years, you are still a rat b@stard.

The problem is that we fear death, as life is all that we "know". The human race is still tribal; "my family and I have more right to X than anyone else's family", etc. and we still extend this thinking on macro levels of communities, state, countries, and continents. There are thoughts that this is inherent because of our evolution, and there are thoughts that if we weren't brought up in a world of "scarcity" we would not act this way (www.thevenusproject.com). Which is true? Well, if Muhammed wrote, "the Jew is thy brother", why is there a problem in the Middle East?

Cue Beavis & Butt Head style sniggering...