One of the great things about the Apollo program was the way it stimulated new technology, an interest in science, and an understanding of systems management. Repeating the exercise will not have the same revolutionary effect, and let's face it, there is absolutely nothing on the Moon of value.
Mining Helium-3 on the Moon is pseudo science. No real evidence the He3 exists in a recoverable form, no sign that a working fusion reactor will exist anytime soon, and helium is not a good fuel because of its stronger electrostatic mutual repulsion of nuclei.
NASA has spent a fortune supporting ISS, something nobel prize physicist Steve Weinberger has called a "flying turkey". There is just no sound scientific reason to maintain a space station in low earth orbit, except as a political exercise. Space tourism is possibly the _only_ good idea to come out of the space station.
If we are going to spend fortune on a new scientific adventure, let's at least do something new. The exploration of the ocean floor is far behind the exploration of Mars. Instead of building the ISS, why didn't we build a permanent manned spacecraft, nuclear powered perhaps, that can visit nearby planets (both the US and USSR designed such crafts decades ago).
If you care about science, rather than pointless exercises in nationalism, then unmanned probes are the way to go. We could learn a great deal from a well funded program of orbiters, landres, rovers and sample-return missions to planets, moons and asteroids.
But I'm with Thomas Friedman, when he suggested that a national program to achieve energy independence would be the best way to stimulate technology and help the nation. I'd gladly turn over the entire NASA budget if I thought it would help us solve the energy problem. We ain't going anywhere in space if we run out of fuel and the world's economy collaspses.