'Nuff said.

CSS is no panacea. You have to totally restructure the flow of many applications in order to present, and allow the management of, information in a way that makes sense, and doesn't totally piss off the user.

Yes, you can use CSS to optimize a layout for various clients, but once you start to deal with any real sort of volume of information, you have to start to refactor the GUI.

Google already do this...

Since when has "Glitches" been used as a synonym for "Totally f'ing unusable"?